The endothelium is a thin membrane that coats the inside of blood vessels and the heart. The inner layer lines the heart chambers and is made of endothelial cells. The layer assists in the regulation of mechanisms involved in blood clotting. The endothelium is a layer of cells on the inside of blood vessels and the heart. Branches of the heart’s conduction system are immersed into the subendocardial layer. Far from being inert, it is metabolically active and produces a variety of vasoactive mediators. Epicardium: the outer protective layer of the heart. The tone of the endothelial layer also determines how much work is needed from the heart to pump blood through the body. Endothelium is a specialized type of epithelium found in the lining of blood and lymphatic vessels. It is the cardiac muscle that enables the heart to contract and allows for the synchronization of the heartbeat. The endothelium is vital to the proper functioning in the heart, in particular due to its production of nitric oxide (NO) which regulates vascular tone. The heart wall is divided into three layers: epicardium, myocardium, and endocardium. As mentioned earlier the endothelial cells do a lot more than just regulate blood flow with nitric oxide, so damaging them has many other consequences. The endothelial cells ultimately determine the health of your blood vessels and play a … Because it is adjacent to the bloodstream, the endothelium can signal a blood vessel’s muscle to respond to changes in pressure and inflammation. The vascular endothelium is a monolayer of cells between the vessel lumen and the vascular smooth muscle cells. The endothelium, which forms the inner cell lining of all blood vessels and lymphatics in the body, is a spatially distributed organ. Furthermore, this tissue has an embryonic mesodermal origin. Endothelium cells help to control toxic substances in the blood. Endothelia are considered the “brains” of blood vessels. It plays a number of roles that are important for the functioning of the cardiovascular system. Superiorly, is the second layer: a subendocardial connective tissue which is continuous with the connective tissue of the myocardium. The endothelium weighs approximately 1 kg in the average patient and covers a total surface area of 4000 to 7000 square meters. Damaged endothelium therefore contributes to hypertension. Damage to the endothelium contributes to the development of atherosclerosis, and hence to possible myocardial infarction and subsequent heart failu … The heart wall is composed of connective tissue, endothelium, and cardiac muscle. The body tries to compensate for this by ordering the heart to pump harder to maintain normal flow by raising the blood pressure. Also, it lines the heart cavities. 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